HORDB

ID: hor001840
Uniprot ID: Q69GG1
Protein name: Pea-FMRFa-18
Gene name: NA
Organism: Periplaneta americana (American cockroach) (Blatta americana)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: GRPSNNFVRF
Length: 10
Propeptide: MGVGIIIAMHALFFFMYHIASSDVLDGTNTIDNVAALDISEDEDDCEPESSITSLPLKRAEEQNQPPPVRRRCSNRNFVRLGRGHDFDQDDVNSSGEKDESLVRIGRGGRSNDNFIRFGRGGKNDNFIRFGRGGKQDNFIRFGRDRSDNFIRFGRGKTDNFIRFGRGRSDNFIRFGRGKSDNFIRFGRARPDNFIRFGRGKQDFIRFGRGNSNFVRFGRDDSSNVETFDTEEEATTDSTLRVGRGGKSGSNFIRFGRARPSSNFIRLGRRDEEVTQREERGRPSNNFVRFGRQTEDDDKFVRLSRSGNSNELRRGKLTDRNFIRLGRSGPSYDEKEQENEDGNSVRLGRSENPSNSRNFIRLGKRALDQNLLVDEHLMRFGRDVEQIENTPVASSGEPSRSDTDNKTKENYQQSRSKRSISFSEEDSSEDSSDYPVMIPNSAYDDVKIPSPSVEDSQIPFRYYSPLSSGIPNYILGPELSVLPPLSNESKRGRGDGHNRNYIRLG
Signal peptide: MGVGIIIAMHALFFFMYHIASS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Excitatory effects of antenna–heart;reduce the spike frequency of dorsal‐unpaired median neurons and reduce the intracellular calcium concentration
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001840_AF2.pdb

hor001840_ESM.pdb

Mass:	135402	Formula:	C53H80N18O14
Absent amino acids:	ACDEHIKLMQTWY	Common amino acids:	FNR
pI:	12.5	Basic residues:	2
Polar residues:	4	Hydrophobic residues:	3
Hydrophobicity:	-90	Boman Index:	-3558
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	29
Instability Index:	3249	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 15355317
Title: Unique accumulation of neuropeptides in an insect: FMRFamide-related peptides in the cockroach, Periplaneta americana